Enetra

Enetra may be available in the countries listed below.

Ingredient matches for Enetra

Nimesulide

Nimesulide is reported as an ingredient of Enetra in the following countries:

• Bulgaria


• Georgia

International Drug Name Search

Elcitonin

Elcitonin may be available in the countries listed below.

Ingredient matches for Elcitonin

Elcatonin

Elcatonin is reported as an ingredient of Elcitonin in the following countries:

• China


• Japan

International Drug Name Search

Exodus

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Exodus

Moxidectin

Moxidectin is reported as an ingredient of Exodus in the following countries:

• New Zealand

Pyrantel

Pyrantel embonate (a derivative of Pyrantel) is reported as an ingredient of Exodus in the following countries:

• United States

Selenium

Selenium is reported as an ingredient of Exodus in the following countries:

• New Zealand

International Drug Name Search

Selen

Selen may be available in the countries listed below.

Ingredient matches for Selen

Sodium Selenite

Sodium Selenite pentahydrate (a derivative of Sodium Selenite) is reported as an ingredient of Selen in the following countries:

• Germany

International Drug Name Search

Succinimide Pharbiol

Succinimide Pharbiol may be available in the countries listed below.

Ingredient matches for Succinimide Pharbiol

Succinimide

Succinimide is reported as an ingredient of Succinimide Pharbiol in the following countries:

• Monaco

International Drug Name Search

raltitrexed Intravenous

ral-ti-TREX-ed

Available Dosage Forms:

• Powder for Solution

Therapeutic Class: Antineoplastic Agent

Pharmacologic Class: Antimetabolite

Uses For raltitrexed

Raltitrexed belongs to a group of medicines known as antimetabolites. It is used to treat cancer of the colon and rectum. It may also be used to treat other kinds of cancer, as determined by your doctor.

Raltitrexed blocks an enzyme needed by the cell to live. This interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by raltitrexed, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern.

Before you begin treatment with raltitrexed, you and your doctor should talk about the good raltitrexed will do as well as the risks of using it.

Raltitrexed is to be administered only by or under the immediate supervision of your doctor.

Before Using raltitrexed

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For raltitrexed, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to raltitrexed or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on raltitrexed have been done only in adult patients, and there is no specific information comparing use of raltitrexed in children with use in other age groups.

Geriatric

Elderly people are especially sensitive to the effects of raltitrexed. Raltitrexed may be more likely to cause side effects such as cracked lips, diarrhea, difficulty in swallowing, sores, ulcers, or white spots on the lips, tongue, or inside the mouth in elderly patients.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking raltitrexed, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using raltitrexed with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Rotavirus Vaccine, Live

Using raltitrexed with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Adenovirus Vaccine Type 4, Live


• Adenovirus Vaccine Type 7, Live


• Bacillus of Calmette and Guerin Vaccine, Live


• Influenza Virus Vaccine, Live


• Measles Virus Vaccine, Live


• Mumps Virus Vaccine, Live


• Rotavirus Vaccine, Live


• Rubella Virus Vaccine, Live


• Smallpox Vaccine


• Typhoid Vaccine


• Varicella Virus Vaccine


• Yellow Fever Vaccine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of raltitrexed. Make sure you tell your doctor if you have any other medical problems, especially:

• Chickenpox (including recent exposure) or


• Herpes zoster (shingles)—Risk of severe disease affecting other parts of the body

• Infection—Raltitrexed can decrease your body's ability to fight infection

• Kidney disease or


• Liver disease—Effects of raltitrexed may be increased because of slower removal from the body; your doctor may need to change your dose

Proper Use of raltitrexed

raltitrexed is sometimes given together with certain other medicines. If you are using a combination of medicines, it is important that you receive each one at the proper time. If you are taking some of these medicines by mouth, ask your health care professional to help you plan a way to take them at the right times.

raltitrexed usually causes nausea and vomiting that may be severe. However, it is very important that you continue to receive the medicine, even if you begin to feel ill. Ask your health care professional for ways to lessen these effects, especially if they are severe.

Dosing

The dose of raltitrexed will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of raltitrexed. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For parenteral dosage form (injection):
  
  • For colorectal cancer
    
    • Adults—3 milligrams (mg) per square meter of body surface area given over a 15 minute period. The dose may be repeated every 3 weeks.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

Call your doctor or pharmacist for instructions.

Precautions While Using raltitrexed

It is very important that your doctor check your progress at regular visits to make sure that raltitrexed is working properly and to check for unwanted effects.

raltitrexed may cause some people to feel unusually tired or ill. Make sure you know how you react to raltitrexed before you drive, use machines, or do anything else that could be dangerous if you are less alert.

While you are being treated with raltitrexed, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval. Raltitrexed may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent. In addition, other persons living in your household should not take oral polio vaccine since there is a chance they could pass the polio virus on to you. Also, avoid persons who have taken oral polio vaccine within the last several months. Do not get close to them and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth.

Raltitrexed can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:

• If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.


• Check with your doctor immediately if you notice any unusual bleeding or bruising; black, tarry stools; blood in urine or stools; or pinpoint red spots on your skin.


• Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.


• Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.


• Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters.


• Avoid contact sports or other situations where bruising or injury could occur.

raltitrexed Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Pale skin, troubled breathing, unusual bleeding or bruising, unusual tiredness or weakness


• black, tarry stools, chest pain, chills, cough, fever, painful or difficult urination, shortness of breath, sore throat, sores, ulcers, or white spots on lips or in mouth, swollen glands


• increase in bowel movements, loose stools, soft stools

Less common

• Dizziness, fainting, fast, slow, or irregular heartbeat, decreased urine output, dilated neck veins, extreme fatigue, irregular breathing, swelling of face, fingers, feet, or lower legs, tightness in chest, weight gain, wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Stomach or abdomen pain


• loss of appetite, weight loss


• constipation


• nausea and vomiting


• lack or loss of strength


• general feeling of discomfort or illness, headache, joint pain, muscle aches and pains, runny nose, shivering, sweating, trouble sleeping


• rash

Less common

• Bloating or swelling of face, arms, hands, lower legs, or feet, rapid weight gain, tingling of hands or feet

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Hair loss, thinning of hair

Less common

• Change in taste, bad unusual or unpleasant (after)taste

After you stop using raltitrexed, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

• Black, tarry stools, blood in urine or stools, cough or hoarseness, fever or chills, lower back or side pain, painful or difficult urination, pinpoint red spots on skin, unusual bleeding or bruising

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

DoxaLEK

DoxaLEK may be available in the countries listed below.

Ingredient matches for DoxaLEK

Doxazosin

Doxazosin is reported as an ingredient of DoxaLEK in the following countries:

• Poland

International Drug Name Search

Oracea

Generic Name: doxycycline (Oral route)

dox-i-SYE-kleen

Commonly used brand name(s)

In the U.S.

• Adoxa


• Adoxa CK


• Adoxa Pak


• Adoxa TT


• Alodox


• Doryx


• Monodox


• Oracea


• Periostat


• Vibramycin Calcium


• Vibramycin Hyclate


• Vibramycin Monohydrate


• Vibra-Tabs

Available Dosage Forms:

• Tablet


• Powder for Suspension


• Capsule


• Capsule, Extended Release


• Tablet, Delayed Release


• Capsule, Delayed Release


• Syrup

Therapeutic Class: Antibiotic

Chemical Class: Tetracycline (class)

Uses For Oracea

Doxycycline is used to treat bacterial infections in many different parts of the body. It is also used to treat pimples and abscesses (usually on the face) that are caused by rosacea, also known as acne rosacea or adult acne.

Doxycycline delayed-release tablets are also used to prevent malaria and treat anthrax infection after possible exposure and other problems as determined by your doctor.

Doxycycline belongs to the class of medicines known as tetracycline antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Before Using Oracea

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Doxycycline may cause permanent discoloration of the teeth and slow down the growth of bones. This medicine should not be given to children 8 years of age and younger (except for treatment of exposure to inhalational anthrax), unless directed by the child's doctor.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of doxycycline in the elderly. However, elderly patients are more likely to have kidney, liver, or heart problems which may require caution and an adjustment in the dose for patients receiving doxycycline.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Acitretin

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Digoxin


• Isotretinoin


• Methotrexate

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Aluminum Carbonate, Basic


• Aluminum Hydroxide


• Aluminum Phosphate


• Bismuth Subsalicylate


• Calcium


• Desogestrel


• Dienogest


• Dihydroxyaluminum Aminoacetate


• Dihydroxyaluminum Sodium Carbonate


• Drospirenone


• Estradiol Cypionate


• Estradiol Valerate


• Ethinyl Estradiol


• Ethynodiol Diacetate


• Etonogestrel


• Fosphenytoin


• Iron


• Levonorgestrel


• Magaldrate


• Magnesium Carbonate


• Magnesium Hydroxide


• Magnesium Oxide


• Magnesium Trisilicate


• Medroxyprogesterone Acetate


• Mestranol


• Norelgestromin


• Norethindrone


• Norgestimate


• Norgestrel


• Penicillin G


• Penicillin G Procaine


• Penicillin V


• Rifampin


• Rifapentine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Diarrhea or


• Vaginal candidiasis (yeast) infections—Use with caution. May make these conditions worse.

• Kidney problems—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of doxycycline

This section provides information on the proper use of a number of products that contain doxycycline. It may not be specific to Oracea. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

To help clear up your infection completely, keep taking this medicine for the full time of treatment, even if you begin to feel better after a few days. If you stop taking this medicine too soon, your symptoms may return.

If you are using Doryx® delayed-release tablets:

• It may be taken with food or milk, if it upsets your stomach.


• You may take this medicine by breaking the tablets. Hold the tablet between your thumb and index fingers close to the appropriate score (separation) line. Then, apply enough pressure to snap the tablet segments apart. Do not use the tablet if it does not break on the scored lines.


• You may also take this medicine by sprinkling the equally broken tablets onto cold, soft food such as an applesauce. This mixture must be swallowed immediately without chewing and followed with a glass of cool water to ensure complete swallowing of the pellets. Do not store the mixture for later use.


• Drink plenty of fluids to avoid throat irritation and ulceration.

If you are using this medicine to prevent malaria while traveling, start taking the medicine 1 or 2 days before you travel. Take the medicine every day during your trip and continue taking it for 4 weeks after you return. However, do not use the medicine for longer than 4 months.

If you are using For Oracea™ delayed-release capsules:

• You should take this medicine on an empty stomach, preferably at least 1 hour before or 2 hours after meals.


• You should take this medicine with a full glass of water while sitting or standing.


• To prevent throat irritation, do not lay down right after taking this medicine.

Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (delayed-release tablets):
  
  • For infections:
    
    • Adults—100 milligrams (mg) every 12 hours on the first day, then 100 mg once a day or 50 to 100 mg every 12 hours.
    
    
    • Children older than 8 years of age who weigh 45 kg or less—Dose is based on body weight and must be determined by your doctor. The dose is usually 4.4 milligrams (mg) per kilogram (kg) of body weight per day and divided into two doses on the first day of treatment. This is followed by 2.2 mg per kg of body weight per day, taken as a single dose or divided into two doses on the following days.
    
    
    • Children up to 8 years of age—Use is not recommended.
    
    
  
  
  • For the prevention of malaria:
    
    • Adults—100 milligrams (mg) once a day. You should take the first dose one or two days before travel to an area where malaria may occur, and continue taking the medicine every day throughout travel and for 4 weeks after you leave the malarious area.
    
    
    • Children older than 8 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 2 milligrams (mg) per kilogram (kg) of body weight per day, taken as a single dose. You should take the first dose one or two days before travel to an area where malaria may occur, and continue taking the medicine every day throughout travel and for 4 weeks after you leave the malarious area.
    
    
    • Children up to 8 years of age—Use is not recommended.
    
    
  
  


• For oral dosage form (delayed-release capsules):
  
  • For the treatment of pimples from rosacea:
    
    • Adults—40 milligrams (mg) or one capsule once a day, in the morning.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Oracea

If your symptoms do not improve within a few days, or if they become worse, check with your doctor.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away.

This medicine may darken the color of your skin, nails, eyes, teeth, gums, or scars. Talk with your doctor if you have any concerns.

Doxycycline may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop taking this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

Birth control pills (containing estrogen) may not work properly while you are using doxycycline. To keep from getting pregnant, use other forms of birth control. These include condoms, diaphragms, or contraceptive foams or jellies.

Doxycycline may cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. When you begin taking this medicine:

• Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible.


• Wear protective clothing, including a hat. Also, wear sunglasses.


• Apply a sunblock product that has a skin protection factor (SPF) number of at least 15. Some patients may require a product with a higher SPF number, especially if they have a fair complexion. If you have any questions about this, check with your doctor.


• Apply a sunblock lipstick that has an SPF of at least 15 to protect your lips.


• Do not use a sun lamp or tanning bed or booth.

If you have a severe reaction from the sun, check with your doctor.

Contact your doctor immediately if fever, rash, joint pain, or tiredness occurs. These could be symptoms of an autoimmune syndrome where the body attacks itself.

You should not take antacids that contain aluminum, calcium or magnesium, or any product that contains iron such as vitamin or mineral supplements.

If you are using this medicine to prevent malaria, take extra care not to get bitten by mosquitoes. Use protective clothing, mosquito netting or screens, and an insect repellent.

Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Oracea Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

• Abdominal or stomach tenderness


• bloating


• clay-colored stools


• cough


• dark urine


• decreased appetite


• diarrhea


• diarrhea, watery and severe, which may also be bloody


• difficulty with swallowing


• dizziness


• fast heartbeat


• feeling of discomfort


• fever


• headache


• hives, itching, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• hives or welts


• increased thirst


• inflammation of the joints


• itching


• joint or muscle pain


• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs


• loss of appetite


• nausea and vomiting


• numbness or tingling of the face, hands, or feet


• pain


• rash


• redness and soreness of the eyes


• redness of the skin


• shortness of breath


• sore throat


• sores in the mouth


• stomach cramps


• stomach pain or tenderness


• swelling of the feet or lower legs


• swollen lymph glands


• tightness in the chest


• unusual tiredness or weakness


• unusual weight loss


• wheezing


• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Back, leg, or stomach pains


• black, tarry stools


• bleeding gums


• blood in the urine or stools


• blurred vision


• bulging soft spot on the head of an infant


• change in the ability to see colors, especially blue or yellow


• chest pain, discomfort, or burning


• chills


• cracks in the skin


• decrease in vision


• difficulty breathing


• discoloration of the thyroid glands


• double vision


• general body swelling


• heartburn


• increased sensitivity of the skin to sunlight


• loss of heat from the body


• lower back or side pain


• nosebleeds


• pain or burning in the throat


• pain with swallowing


• painful or difficult urination


• pale skin


• pinpoint red spots on the skin


• rash with flat lesions or small raised lesions on the skin


• red, swollen skin


• redness or other discoloration of the skin


• redness, swelling, or soreness of the tongue


• scaly skin


• severe nausea


• severe stomach pain


• severe sunburn


• sores, ulcers, or white spots on the lips or tongue or inside the mouth


• unusual bleeding or bruising


• vomiting blood

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Oracea side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Oracea resources

• Oracea Side Effects (in more detail)
• Oracea Use in Pregnancy & Breastfeeding
• Oracea Drug Interactions
• Oracea Support Group
• 14 Reviews for Oracea - Add your own review/rating

• Oracea Prescribing Information (FDA)


• Oracea Consumer Overview


• Oracea Monograph (AHFS DI)


• Doxycycline Prescribing Information (FDA)


• Doxycycline MedFacts Consumer Leaflet (Wolters Kluwer)


• Doxycycline Professional Patient Advice (Wolters Kluwer)


• Adoxa MedFacts Consumer Leaflet (Wolters Kluwer)


• Alodox Prescribing Information (FDA)


• Doryx Prescribing Information (FDA)


• Doryx Delayed-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)


• Doxycycline Calcium Monograph (AHFS DI)


• Monodox Prescribing Information (FDA)


• Ocudox Convenience Kit MedFacts Consumer Leaflet (Wolters Kluwer)


• Periostat MedFacts Consumer Leaflet (Wolters Kluwer)


• Periostat Prescribing Information (FDA)


• Vibra-Tabs MedFacts Consumer Leaflet (Wolters Kluwer)


• Vibramycin Prescribing Information (FDA)

Compare Oracea with other medications

• Ocular Rosacea
• Rosacea

Qualiprinol

Qualiprinol may be available in the countries listed below.

Ingredient matches for Qualiprinol

Inosine Pranobex

Inosine Pranobex is reported as an ingredient of Qualiprinol in the following countries:

• Hong Kong

International Drug Name Search

Dextrose Injection

Dosage Form: injection, solution
50% and 70% Dextrose Injection, USP

Pharmacy Bulk Package

Not for Direct Infusion

VIAFLEX Plastic Container

A Parenteral Nutrient

Dextrose Injection Description

Dextrose Injections, USP are sterile, nonpyrogenic hypertonic solutions for fluid replenishment and caloric supply in Pharmacy Bulk Package. A Pharmacy Bulk Package is a container of sterile preparation for parenteral use that contains many single doses. The contents are intended for use in a pharmacy admixture program and are restricted to the preparation of admixtures for intravenous infusion. They contain no antimicrobial agents. Composition, osmolarity, pH, and caloric content are shown below.

Table 1

	Composition	Osmolarity		Caloric Content	How Supplied
	Dextrose Hydrous, USP (g/L)	(mOsmol/L) (calc.)	pH	(kcal/L)	Size, code, NDC
					2000 mL unit
50% Dextrose Injection, USP	500	2520	4.0 (3.2 to 6.5)	1710	2B0256 NDC 0338-0031-06
70% Dextrose Injection, USP	700	3530	4.0 (3.2 to 6.5)	2390	2B0296 NDC 0338-0719-06

The VIAFLEX plastic container is fabricated from a specially formulated polyvinyl choloride (PL 146 Plastic). Exposure to temperatures above 25°C/77°F during transport and storage will lead to minor losses in moisture content. Higher temperatures lead to greater losses. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period. The amount of water that can permeate from inside the container into the overwrap is insufficient to affect the solution significantly.

Solutions in contact with the plastic container can leach out certain of its chemical components in very small amounts within the expiration period, e.g., di-2-ethylhexyl phthalate (DEHP), up to 5 parts per million. However, the safety of the plastic has been confirmed in tests in animals according to USP biological tests for plastic containers as well as tissue culture toxicity studies.

Dextrose Injection - Clinical Pharmacology

Dextrose Injections, USP have value as a source of water and calories. They are capable of inducing diuresis depending on the clinical condition of the patient.

Indications and Usage for Dextrose Injection

Dextrose Injections, USP are indicated as a caloric component in a parenteral nutrition regimen. They are used with an appropriate protein (nitrogen) source in the prevention of nitrogen loss or in the treatment of negative nitrogen balance in patients where: (1) the alimentary tract cannot or should not be used, (2) gastrointestinal absorption of protein is impaired, or (3) metabolic requirements for protein are substantially increased, as with extensive burns

Contraindications

The infusion of hypertonic Dextrose Injections is contraindicated in patients having intracranial or intraspinal hemorrhage, in patients who are severely dehydrated, in patients who are anuric, and in patients in hepatic coma.

Solutions containing dextrose may be contraindicated in patients with known allergy to corn or corn products.

Warnings

These injections are for compounding only, not for direct infusion.

Dilute before use to a concentration which will, when administered with an amino acid (nitrogen) source, result in an appropriate calorie to gram of nitrogen ratio and which has an osmolarity consistent with the route of administration.

Unless appropriately diluted, the infusion of hypertonic Dextrose Injection into a peripheral vein may result in vein irritation, vein damage, and thrombosis. Strongly hypertonic nutrient solutions should only be administered through an indwelling intravenous catheter with the tip located in a large central vein such as the superior vena cava.

In very low birth weight infants, excessive or rapid administration of Dextrose Injection may result in increased serum osmolality and possible intracerebral hemorrhage.

WARNING: This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum.

Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 µg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration.

Administration by central venous catheter should be used only by those familiar with this technique and its complications.

Precautions

Administration of hypertonic dextrose and amino acid solutions via central venous catheter may be associated with complications which can be prevented or minimized by careful attention to all aspects of the procedure. This includes attention to solution preparation, administration and patient monitoring.

It is essential that carefully prepared protocol, based upon current medical practice, be followed, preferably by an experienced team.

The package insert of the protein (nitrogen) source should be consulted for dosage and all precautionary information.

Clinical evaluation and periodic laboratory determinations are necessary to monitor changes in fluid balance, electrolyte concentration, and acid base balance during prolonged parenteral therapy or whenever the conditions of the patient warrants such evaluation.

Care should be taken to avoid circulatory overload, particularly in patients with cardiac insufficiency.

Caution must be exercised in the administration of these injections to patients receiving corticosteroids or corticotropin.

These injections should be used with caution in patients with overt or subclinical diabetes mellitus.

Drug product contains no more than 25 µg//L of aluminum.

Carcinogenesis, Mutagenesis, Impairment of Fertility

Studies with 50% and 70% Dextrose Injection, USP have not been performed to evaluate carcinogenic potential, mutagenic potential, or effects on fertility.

Pregnancy

Teratogenic Effects

Pregnancy Category C

Animal reproduction studies have not been conducted with Dextrose Injections, USP. It is also not known whether Dextrose Injections, USP can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Dextrose Injections, USP should be given to a pregnant woman only if clearly needed.

Nursing Mothers

Caution should be exercised when 50% and 70% Dextrose Injection, USP is administered to a nursing woman

Pediatric Use

Dextrose is safe and effective for the stated indications in pediatric patients (see INDICATIONS AND USAGE. As reported in the literature, the dosage selection and constant infusion rate of intravenous dextrose must be selected with caution in pediatric patients, particularly neonates and low birth weight infants, because of the increased risk of hyperglycemia/hypoglycemia. Frequent monitoring of serum glucose concentrations is required when dextrose is prescribed to pediatric patients, particularly neonates and low birth weight infants. Because of their hypertonicity, 50% and 70% Dextrose Injections must be diluted prior to administration.

Adverse Reactions

Too rapid infusion of a hypertonic dextrose solution may result in diuresis, hyperglycemia, glycosuria, and hyperosmolar coma. Continual clinical monitoring of the patient is necessary in order to identify and initiate measures for these clinical conditions.

Reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation and hypervolemia.

If an adverse reaction does occur discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures, and save the remainder of the fluid for examination if deemed necessary.

Dextrose Injection Dosage and Administration

Following suitable admixture of prescribed drugs, the dosage is usually dependent upon age, weight and clinical condition of the patient as well as laboratory determinations. See directions accompanying drugs.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.

Do not administer unless solution is clear and seal is intact.

Use of a final filter is recommended during administration of all parenteral solutions where possible.

50% and 70% Dextrose Injection, USP in the Pharmacy Bulk Package is intended for use in the preparation of sterile, intravenous admixtures. Additives may be incompatible with the fluid withdrawn from this container. Complete information is not available. Those additives known to be incompatible should not be used. Consult with pharmacist, if available. When compounding admixtures, use aseptic technique. Mix thoroughly. Do not store any unused portion of the 50% and 70% Dextrose Injection, USP.

DIRECTIONS FOR USE OF VIAFLEX PLASTIC PHARMACY BULK PACKAGE CONTAINER

To Open

Tear overpouch at slit and remove solution container. Some opacity of the plastic due to moisture absorption during the sterilization process may be observed. This is normal and does not affect the solution quality or safety. The opacity will diminish gradually. Check for minute leaks by squeezing inner bag firmly. If leaks are found, discard solution as sterility may be impaired.

For compounding only, not for direct infusion.

Preparation for Admixing

1. The Pharmacy Bulk Package is to be used only in a suitable work area such as a laminar flow hood (or an equivalent clean air compounding area).


2. Suspend container from eyelet support.


3. Remove plastic protector from outlet port at bottom of container.


4. Attach solution transfer set. Refer to complete directions accompanying set.
   

   Note: The closure shall be penetrated only one time with a suitable sterile transfer device or dispensing set which allows measured dispensing of the contents.

   
   


5. The VIAFLEX plastic container should not be written on directly since ink migration has not been investigated. Affix accompanying label for date and time of entry notation.


6. Once container closure has been penetrated, withdrawal of contents should be completed without delay. After initial entry, maintain contents at room temperature (25°C/77°F) and dispense within 4 hours.

How is Dextrose Injection Supplied

See Table 1 .

Exposure of pharmaceutical products to heat should be minimized. Avoid excessive heat. Protect from freezing. It is recommended the product be stored at room temperature (25°C/77°F).

BAR CODE PLACEMENT

071938462

Baxter Healthcare Corporation

Clintec Nutrition Division

Deerfield, IL 60015 USA

Printed in USA

BAXTER, VIAPLEX, and PL 146 are trademarks of Baxter International, Inc.

07-19-38-462

Rev. May 2003

Distributed in Canada by

Baxter Corporation

Toronto, Ontario, Canada

PACKAGE LABELING - PRINCIPAL DISPLAY PANEL

Container Label

LOT

EXP

2B0296

NDC 0338-0719-06

2000 mL

DIN 02014874

DEXTROSE

Injection USP

70%

Pharmacy Bulk Package

Not For Direct Infusion

Must Be Diluted

Rx Only

EACH 100 mL CONTAINS 70 g DEXTROSE HYDROUS USP

IN WATER FOR INJECTION USP

pH 4.0 (3.2 to 6.5) SPECIFIC GRAVITY 1.24 (CALC)

HYPERTONIC OSMOLARITY 3530 mOsmol/L (CALC)

STERILE NONPYROGENIC

CONTAINS NO MORE THAN 25 µg/L OF ALUMINUM

COLOR VARIATION FROM LIGHT YELLOW TO AMBER IS NORMAL

AND DOES NOT ALTER EFFICACY

DOSAGE AND ADMINISTRATION SEE PACKAGE INSERT

CAUTION DO NOT USE UNLESS SOLUTION IS CLEAR CLOSURE

IS INTACT AND CONTAINER IS UNDAMAGED

CHECK FOR MINUTE LEAKS BY SQUEEZING FIRMLY

IF LEAKS ARE FOUND DISCARD AS STERILITY MAY BE IMPAIRED

AFFIX ACCOMPANYING LABEL FOR DATE AND TIME OF ENTRY

WITHIN 4 HOURS AFTER INITIAL ENTRY DISCARD CONTAINER

AND UNUSED CONTENTS

STORE UNIT IN MOISTURE BARRIER OVERWRAP AT

ROOM TEMPERATURE (25°C/77°F) UNTIL READY TO USE

AVOID EXCESSIVE HEAT PROTECT FROM FREEZING

VIAFLAX CONTAINER

PL 146 PLASTIC

Baxter

BAXTER HEALTHCARE CORPORATION

CLINTEC NUTRITION DIVISION

DEERFIELD IL 60015 USA

DISTRIBUTED IN CANADA BY

BAXTER CORPORATION

TORONTO ONTARIO CANADA

MADE IN USA

BAXTER PL 146

AND VIAFLEX ARE

TRADEMARKS OF BAXTER

INTERNATIONAL INC

70%

Carton Label

2B0256H

6 - 2000ML

VIAFLEX CONTAINER

70% Dextrose Injection, USP

(70% DEXTROSE IN WATER)

PROTECT FROM FREEZING

EXP

XXXXX

SECONDARY BAR CODE

(17) YYMM00 (10) XXXXX

LOT

XXXXX

PRIMARY BAR CODE

(01) 50303380719063

DEXTROSE  dextrose monohydrate  injection, solution

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 0338-0031 Route of Administration INTRAVENOUS DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength DEXTROSE MONOHYDRATE (DEXTROSE) DEXTROSE MONOHYDRATE 500 g  in 1000 mL

Inactive Ingredients Ingredient Name Strength Water

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 0338-0031-06 2000 mL In 1 BAG None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
ANDA	ANDA020047	03/14/2011

DEXTROSE  dextrose monohydrate  injection, solution

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 0338-0719 Route of Administration INTRAVENOUS DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength DEXTROSE MONOHYDRATE (DEXTROSE) DEXTROSE MONOHYDRATE 700 g  in 1000 mL

Inactive Ingredients Ingredient Name Strength Water

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 0338-0719-06 2000 mL In 1 BAG None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
ANDA	ANDA020047	03/14/2011

Labeler - Baxter Healthcare Corporation (005083209)

Establishment
Name	Address	ID/FEI	Operations
Baxter Healthcare Corporation		059140764	MANUFACTURE

Revised: 01/2012Baxter Healthcare Corporation